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KMID : 1098420090170060470
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Korean Journal of Medicinal Crop Science
2009 Volume.17 No. 6 p.470 ~ p.474
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Effects of Achyrantes japonica on Carrageenan-Induced Arthritis Rat Model
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Kim Young-Ock
Lee Sang-Won
Lee Seung-Eun
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Abstract
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Achyrantes japonica (AJ) has been used to treat edema and arthritis in the traditional Korean medicine. To elucidate the anti-inflammatory and anti-nociceptive effects of ethanol extract of AJ, the carrageenan-induced paw edema using a plethysmometer and thermal hypersensitivity using the plantar test were measured. Ibuprofen was used as a control drug. Treatment with AJ (200㎎/kg p.o.) significantly reduced paw edema, compared to the carrageenan - treated rats. In the plantar test, the thermal withdrawal latency in AJ - treated group was significantly increased than the carrageenan - treated group. The results indicate that AJ could have be the anti-inflammatory and anti-nociceptive properties.
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KEYWORD
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Achyrantes japonica, Inflammation, Nociception, paw Edema
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